ImmunoBioPharmaseuticals Lab

Representative publications
Highlighting key research works from Son Lab that shaped the field of immune engineering and nanomedicine.
S. Son et al,
Nat. Biomed. Eng, Vol 7, Issue 1
(2023)
J. Nam et al,
Adv. Sci., Vol 8, Issue 5
(2021)
S. Son et al,
Nano Lett., Vol 20, Issue 3
(2020)
J. Nam et al,
Nat Rev Mater., Vol 4, Issue 6
(2019)
PEER-REVIEWED PUBLICATIONS (> 5200 citations, h-index = 32)
For our most recent publications, please visit google scholar.
(*: Authors contributed equally, #: corresponding author)
Journal Articles:
53.
Jeong Hyun Moon*, May Thazin Phoo*, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam,
Soo-Hong Lee, James J. Moon, Sejin Son#
Advenced Science (2025), Early View
(IF=14.1, Top 7.0 %)

52.
Rational bioengineering of polysaccharide in designing of microbiome modulation.
Jeong Hyun Moon*, Kidong Kim, Yubin Kim, Sejin Son#
Trends in Biothechnology (2025), online published
(IF=14.9, Top 1.4 %)
Keyword:
- Polysaccharide
- Microbiome modulation
- Prebiotics
- Probiotics
- Immune modulation

51.
Emerging nano-vaccine technologies to overcome anti-microbial resistance.
Hyeyong Choi*, Sejin Son#
Journal Of Controlled Release (2025), vol 386, 114076
(IF=11.5, Top 3.3 %)
Keyword:
- Antimicrobial resistance
- Nano-vaccine
- Resistance-targeting vaccines

50.
Khizra Mujahid*, Muhammad Arif Aslam*, Kai Han, Sejin Son#,
Jutaek Nam#
Biomaterials Research (2025), vol 29, 0221
(IF=9.6, Top 8.5%)
Keyword:
- Nanoparticle-based immune checkpoint inhibitor
- Anti-PD-1 antibody
- Polydopamine nanoparticles
- Localized cancer immunotherapy

49.
Bumjun Park, Shirin Movaghgharnezhad, Seung Min Lee, Yonghyeon Park, Sejin Son#,
Yun Suk Huh#, Pilgyu Kang#
Advanced Science (2025), vol 12, 2414607
(IF=14.1, Top 7.1%)

Keyword:
- Graphene nanofibers
- Electrospinning
- Laser graphitization
- Micro-supercapacitors
2025
48.
Colon-adhesive poly (maleic anhydride)‐sirolimus conjugate alleviates local colitis inflammation.
Sang-Hun Choi, Soo-Hyang Chi, Yu-Seong Park, Sejin Son, Young-Eun Cho#, Jihoon Kim#
Journal of Applied Polymer Science (2024), vol 141 (45), e56220
(IF=2.8, Top 50.5%)
Keyword:
- Colitis
- Polymer-drug conjugate
- Sirolimus
- Ulcerative colitis

47.
Development of a Hemoglobin-based Oxygen Carrier Using PEGylation.
Hyemin Cho*, Kidong Kim, Jaeeun Oh, Youngjoon Park, Sejin Son#
Polymer-Korea (2024), vol 48 (5), 449-459
(IF=0.6, Top 96.3%)

Keyword:
- Hemoglobin-based oxygen carrier
- PEGylation
- Polyethylene glycol(PEG)
- Blood substitute
46.
Geonho Cho, Kidong Kim, Weihsuan Chen, Sejin Son, Tae-Joon Jeon, Sun Min Kim
Chemical Engineering Journal (2024), vol 495, 153407.
(IF=13.2, Top 3.0%)

Keyword:
- Nanopore sensing
- Artificial membrane
- Polyethylene
- Paper cup
- Microplastic
- Inflammation
Keyword:
- Polysaccharide
- Immunoadjuvant
- PAMP-PRR interaction
- Vaccine/Immunotherapy

44.
Engineered Polysaccharides for Controlling the Innate and Adaptive Immune Responses.
Jutaek Nam*, April Kim*, Kidong Kim*, Jung Hyun Moon, Juwon Baig, May Phoo, James J. Moon#,
Sejin Son#
Nature Reviews Bioengineering (2024), vol 2 (9), 733-751
(IF=37.6, Top 0.4%)
Keyword:
- Engineered polysaccharides
- Pathogen-recognition receptors (PRRs)
- Immunomodulation
- Vaccine/immunotherapy delivery


Keyword:
- Graphene
- Tetracycline degradation
- Bioimaging
- Zinc oxide nanoparticles
- Bacteria
- Photocatalysis
43.
Aliya Sheik, Kugalur Shangmugam Ranjith, Seyed Majid Ghoreishian, Yujeong Yang, YongHyeon Park, Sejin Son, Young-Kyu Han, Yun Suk Huh
Nature Reviews Bioengineering (2024), vol 2 (9), 733-751
(IF=37.6, Top 0.4%)
2024
42.
Metal-Based Nanoparticles for Cancer Metalloimmunotherapy.
Ivan Hardianto Suliman, Kidong Kim, Weihsuan Chen, Yubin Kim, Jeong-Hyun Moon, Sejin Son#, Jutaek Nam#
Pharmaceutics (2023),vol 15 (7), 2003
(IF=5.5, Top 9.5%)
Keyword:
- Cancer
- Immunotherapy
- Metal ion
- Immune cell regulation
- Metal-based nanoparticle
- Metalloimmunotherapy

41.
Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release.
Deborah Lee, Seoyoon Song, Suheon Kim, Mina Lee, Eunsu Kim, Sunhee Yoon, Han-Ul Kim, Sejin Son, Hyun Suk Jung, Yun Suk Huh, Sun Min Kim#, and Tae-Joon Jeon#
Biomacromolecules (2023), vol 24 (8), 3898-3907
(IF=5.4, Top 4.4%)

40.
Nanocarriers for cancer nano-immunotherapy.
Isra Rana, Jaeeun Oh, Juwon Baig, Jeong-Hyun Moon, Sejin Son#, Jutaek Nam#
Drug Delivery and Translational Research (2023),
vol 13 (7), 1936-1954
(IF=5.5, Top 9.5%)

39.
Induction of T-helper-17-cell-mediated anti-tumour immunity
by pathogen-mimicking polymer nanoparticles.
Sejin Son*#, Jutaek Nam*, April S. Kim, Jinsung Ahn, Kyung Soo Park,
May Thazin Phoo, Brett Sherren, Weiping Zou, Soo-Hong Lee,
Omid C. Farokhzad, Jinjun Shi, James J. Moon#
Nature Biomedical Engineering (2023), vol 7 (1), 72-84
(IF=26.6, Top 1.2%)
Keyword:
- Th17 cells
- Pathogen-mimicking polymer nanoparticles
- Dectin-2/TLR-4 pathway
- Cancer immunotherapy
- Mannan nanocapsule

2023 (Inha Univ.)
Before Inha Univ.
38. Photothermal therapy combined with neoantigen cancer vaccination for effective immunotherapy
against large established tumors and distant metastasis.
Nam J*, Son S*, Park K, Moon J. J.
Advanced Therapeutics (2021), 2100093. (IF=4.6, Top 25.40%)
37. Personalized combination nano-immunotherapy for robust induction and tumor infiltration of
CD8+ T cells.
Park K, Nam J, Son S, Moon J. J.
Biomaterials (2021), 274, 120844. (IF=14, Top 1.32%)
36. Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and
SARS-CoV-2.
Park K, Bazzill J, Son S, Nam J, Shin SW, Stuckey J, Meagher J, Song J, Montefiori DC, LaBranche CC, Smith J, Xu J, and Moon J. J.
Journal of Controlled Release (2021), 330, 529-539. (IF=10.8, Top 3.51%)
35. Modularly programmable nanoparticle vaccine based on polyethyleneimine for personalized c
cancer immunotherapy.
Nam J*, Son S*, Park K, Moon J. J.
Advanced Science (2021), 8 (5), 2002577. (IF=15.1, Top 4.94%)
2021
34. Synthetic high-density lipoprotein nanodiscs for personalized immunotherapy against gliomas.
Scheetz L, Kadiyala P, Sun X, Son S, Najafabadi A, Aikins M, Lowenstein P, Schwendeman A, Castro M, and Moon J. J.
Clinical Cancer Research (2020), 26, 16, 4369-4380. (IF=11.5, Top 8.90%)
33. Sugar-Nanocapsules imprinted with Microbial Molecular Patterns for mRNA Vaccination.
Son S*, Nam J*, Zenkov I, Ochyl LJ, Xu Y, Scheetz L, Shi J, Farokhzad O. C.# Moon J. J.#
Nano Letters (2020), 20, 3, 1499-1509. (IF=10.8, Top 5.74%)
2020
32. Cancer nanomedicine for combination cancer immunotherapy.
Nam J*, Son S*, Park K, Zou W, Shea L. D., Moon J. J.#
Nature Review Materials (2019), 4 (6), 398-414. (IF=83.5, Top 0.18%)
2019
31. Elimination of established tumors with nanodisc-based combination chemoimmunotherapy.
Kuai R*, Yuan W*, Son S, Nam J, Xu Y, Fan Y, Schwendeman A, and Moon J. J.
Science Advances (2018), 4, eaao1736. (IF=13.6, Top 5.07%)
30. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced
metastatic cancer.
Nam J*, Son S*, Ochyl LJ, Kuai R, Schwendeman A, Moon J. J.
Nature Communication (2018), 9, 1074. (IF=16.6, Top 3.91%)
2018
29. Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound.
You DG, Yoon HY, Jeon S, Um W, Son S, Park JH, Kwon IC, Kim K.
Nano convergence (2017), 4, 30. (IF=11.7, Top 7.20%)
28. Adjuvant-loaded spiky gold nanoparticles for activation of innate immune cells.
Nam J, Son S, Moon J. J.
Cellular and molecular bioengineering (2017), 10, 341-355. (IF=2.8, Top 71.53%)
27. Antitumor therapeutic application of self-assembled RNAi-AuNP nanoconstructs: Combination of
VEGF-RNAi and photothermal ablation.
Son S*, Kim N*, You DG, Yoon HY, Yhee JY, Kim K, Kwon IC, Kim SH.
Theranostics (2017), 7, 9. (IF=12.4, Top 6.85%)
2017
26. Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-
triggered drug delivery.
Min HS*, Son S*, You DG, Lee TW, Lee S, Lee J, Han MH, Park JH, Kim SH, Choi K, Park K, Kim, K, Kwon IC.
Biomaterials (2016), 108, 57. (IF=14, Top 1.52%)
25. Reducible polyethylenimine nanoparticles for efficient siRNA delivery in corneal
neovascularization therapy.
Han H*, Son S*, Son S, Kim N, Yhee JY, Lee JH, Choi JS, Joo CK, Lee H, Kim WJ, Kim SH, Kwon, IC, Kim H, Kim K.
Macromolecular Bioscience (2016), 16, 11, 1583, Highlighted in Cover Picture. (IF=4.6, Top 12.80%)
24. ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer.
You DG, Deepagan VG, Um W, Jeon S, Son S, Chang H, Yoon HI, Cho YW, Swierczewska M, Lee S, Pomper MG, Kwon IC, Kim K, Park JH.
Scientific Reports (2016), 6, 23200. (IF=4.6, Top 7.89%)
2016
23. Echogenic glycol chitosan nanoparticles for ultrasound-triggered cancer theranostics.
Min HS, You DG, Son S, Jeon S, Yhee J, Park JH, Lee S, Kwon IC, Kim K.
Theranostics. Highlighted in Cover Picture (2015), 5, 12, 1402-1418. (IF=12.4, Top 6.85%)
22. Nanoparticle-based combination therapy for cancer treatment.
Yhee JY, Son S, Lee H, Kim K.
Current Pharmaceutical Design (2015), 21, 22, 3158-66. (IF=3.1, Top 24.41%)
2015
21. Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to
overcome drug resistance.
Yhee JY, Song S, Lee SJ, Park S, Kim K, Kim MG, Son S, Koo H, Kwon IC, Jeong JH, Jeong SY, Kim SH,
Kim K.
Journal of Controlled Release (2014), 198, 28, 1-9. (IF=10.8, Top 3.64%)
20. Glycol chitosan nanoparticles as highly specialized cancer therapeutic vehicles: Sequential
delivery of doxorubicin and Bcl-2 siRNA.
Yoon HY*, Son S*, Lee SJ, You DG, Yhee JY, Park JH, Swierczewska M, Lee S, Kwon IC, Kim SH, Kim K, Promper Scientific Reports (2014), 4, 6878. (IF=4.6, Top 13.39%)
19. Echogenic nanoparticles for ultrasound technologies; evolution from diagnostic imaging modality
to multimodal theranostic agent.
Son S*, Min HS*, You DG, Kim BS, Kwon IC.
Nano Today (2014), 9, 4, 525-540. (IF=17.4, Top 1.45%)
18. i-motif-driven Au nanomachines in programmed siRNA delivery for gene-silencing and
photothermal ablation.
Son S*, Nam J*, Kim J, Kim S, Kim WJ.
ACS Nano (2014), 8, 6, 5574-5584. (IF=17.1, Top 3.14%)
2014
17. Tumor-targeting Transferrin Nanoparticles for Systemic Polymerized siRNA Delivery in Tumor-
bearing Mice.
Yhee JY, Lee SJ, Lee S, Song S, Min HS, Kang, SW, Son S, Jeong SY, Kim SH, Kim K.
Bioconjugate Chemistry (2013), 24, 11, 1850-1860. (IF=4.7, Top 13.39%)
16. Liver-specific and echogenic hyaluronic acid nanoparticles facilitating liver cancer discrimination.
Min HS*, Son S*, Lee TW, Koo, H, Yoon HY, Na JH, Choi Y, Park JH, Lee J, Han M, Park RW, Kim IS, Jeong SY, Kim SH, Kwon IC, Kim K.
Advanced Functional Materials (2013), 23, 44, 5518-5529. (IF=19, Top 4.09%)
Highlighted in Cover Picture.
15. Structural modification of siRNA for efficient gene silencing.
Lee SJ*, Son S*; Yhee JY, Choi K, Kwon IC, Kim SH, Kim K.
Biotechnology Advances (2013), 31, 5, 491-503. (IF=16, Top 2.22%)
2013
14. A Review of RGD-functionalize non-viral gene delivery vectors for cancer therapy.
Park J, Singha K, Son S, Kim J, Namgung R, Yun CO, Kim WJ.
Cancer Gene Therapy (2012), 19, 741-748. (IF=6.4, Top 20.31%)
13. Bioreducible polymers for gene silencing and delivery.
Son S*, Namgung R, Kim J, Singha K, Kim WJ.
Account of Chemical Research (2012), 45, 1100-1112. (IF=18.3, Top 1.70%)
12. Sustained cytoplasmic delivery and anti-viral effect of PLGA nanoparticles carrying a nucleic acid-
hydrolyzing monoclonal antibody.
Joung YK*, Son S*, Jang JY, Kwon MH, Park KD.
Pharmaceutical Research (2012), 29, 932-942. (IF=3.7, Top 12.90%)
2012
11. Artificial Cell Membrane-mimicking Nanostructure Facilitates Efficient Gene Delivery through
Fusogenic Interaction with the Plasma Membrane of Living Cells.
Son S*, Kim G, Singha K, Park S, Ree M, Kim WJ.
Small (2011), 7, 2991-2997, Highlighted in the frontispiece. (IF=13.3, Top 5.84%)
10. Biodegradable Particulate Delivery of Vascular Endothelial Growth Factor Plasmid from
Polycaprolactone/Polyethylenimine Electrospun Nanofibers for the Treatment of Myocardial Infarction.
Che HL, Muthiah M, Ahn Y, Son S, Kim WJ, Seonwoo H, Chung JH, Cho CS, Park IK.
Journal of Nanoscience and Nanotechnology (2011), 11, 1-5. (IF=1.134, Top 39.95%)
9. A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of
neurogenic microRNA.
Hwang DW, Son S, Jang J, Youn H, Lee S, Lee D, Lee YS, Jeong JM, Kim WJ, Lee DS.
Biomaterials (2011), 32, 4968-4975. (IF=14, Top 2.00%)
8. Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery.
Garripelli VK, Kim JK, Son S, Kim WJ, Repka MA, Jo S.
Acta Biomaterialia (2011), 7, 1984-1992. (IF=9.7, Top 4.24%)
7. RVG peptide tethered bioreducible polyethylenimine for gene delivery to brain.
Son S*, Hwang DW, Singha K, Jeong JH, Park TG, Lee DS, Kim WJ.
Journal of Controlled Release (2011), 155, 18-25. (IF=10.8, Top 5.70%)
6. DNA-functionalized nanochannels for SNP detection.
Yang SY*, Son S*, Jang S, Kim H, Jeon G, Kim WJ, Kim JK.
Nano Letters (2011), 11, 1032-1035. (IF=10.8, Top 3.04%)
5. Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier.
Son S*, Singha K, Kim WJ.
Biomaterials (2011), 31, 6344-6354. (IF=14.0, Top 2.00%)
2011
4. The biocompatibility of self-assembled brush polymers bearing glycine derivatives.
Kim G, Rho Y, Park S, Kim H, Son S, Kim H, Kim IJ, Kim JR, Kim WJ, Ree M.
Biomaterials (2010), 31, 3816-3826. (IF=14.0, Top 2.50%)
3. Biodegradable nanoparticles modified by branched polyethylenimine for plasmid DNA delivery.
Son S*, Kim WJ.
Biomaterials (2010), 31, 133-143. (IF=14.0, Top 2.50%)
2010
2. An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the
myocardium and skeletal muscle cells.
Namgung R, Nam S, Kim SK, Son S, Singha K, Kwon JS, Ahn Y, Jeong MH, Park IK, Garripelli VK, Jo S,
Kim WJ.
Biomaterials (2009), 30, 5225-5233. (IF=14.0, Top 3.12%)
1. Optimized stability retention of a monoclonal antibody in the PLGA nanoparticles.
Son S*, Lee WR, Joung YK, Kwon MH, Kim YS, Park KD.
International Journal of Pharmaceutics (2009), 368,178-185. (IF=5.8, Top 38.29%)
2009



